Endosulfan inhibits proliferation through the Notch signaling pathway in human umbilical vein endothelial cells

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• 作者：Jialiu Wei^a ; ^b ; Lianshuang Zhang^a ; ^b ; Lihua Ren^a ; ^b ; Jin Zhang^a ; ^b ; Yang Yu^a ; ^b ; Ji Wang^a ; ^b ; Junchao Duan^a ; ^b ; Cheng Peng^c ; Zhiwei Sun^a ; ^b ; Xianqing Zhou^a ; ^b ; ^{xqzhou@ccmu.edu.cn} ; ^{xianqingzhou@aliyun.com}
• 关键词：Endosulfan ; Cell cycle arrest ; Cytoskeleton ; Notch signaling pathway ; HUVECs
• 刊名：Environmental Pollution
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：221
• 期：Complete
• 页码：26-36
• 全文大小：3377 K
• 卷排序：221

文摘

Endosulfan induces cell cycle arrest, inhibits proliferation, and causes apoptosis of endothelial cells. Endosulfan activates protein expressions in the Notch signaling pathway. Endosulfan induces toxicity of endothelial cells by activating the Notch signaling pathway. Endosulfan damages the cytoskeleton and blocks mitosis of endothelial cells.