Norovirus in feces and nasopharyngeal swab of children with and without acute gastroenteritis symptoms: First report of GI.5 in Brazil and GI.3 in nasopharyngeal swab

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• 作者：Nathâ ; nia Dá ; billa^a ; Tâ ; mera Nunes Vieira Almeida^a ; Anniely Carvalho Rebouç ; as Oliveira^a ; André ; Kipnis^b ; Thairiny Neres Silva^a ; Fabí ; ola Souza Fiaccadori^a ; Teresinha Teixeira de Sousa^a ; Divina das Dô ; res de Paula Cardoso^a ; Menira Souza^a ; ^{menirasouza@gmail.com}
• 关键词：Norovirus ; Hospitalized children ; Viral load ; NoV in nasopharyngeal swab ; Genotypes ; Asymptomatic NoV infection ; RT-qPCR
• 刊名：Journal of Clinical Virology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：87
• 期：Complete
• 页码：60-66
• 全文大小：772 K
• 卷排序：87

文摘

This is the first investigation of norovirus in fecal and nasopharyngeal swab samples obtained from the same children. We report positivity rates in nasopharyngeal swabs of 11.4% from symptomatic and in 6.5% from asymptomatic children. A considerable genomic variability was found and a higher frequency of GII NoV was detected in fecal samples. This is the first report of GI.3 in nasopharyngeal swab samples and also the first report of GI.5 NoV in Brazil. Findings amplify the need to investigate NoV in respiratory tract of children with and without gastroenteritis.