4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function
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- 作者：Rajaneesh Anupam ; Abhijit Nayek ; Nicholas J. Green ; Frank J. Grundy ; Tina M. Henkin ; John A. Means ; Stephen C. Bergmeier ; Jennifer V. Hines
- 关键词：Oxazolidinone ; RNA ligand ; Riboswitch ; Transcription antitermination ; T box
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2008
- 出版时间：15 June 2008
- 年：2008
- 卷：18
- 期：12
- 页码：3541-3544
- 全文大小：277 K
文摘
The T box transcription antitermination system is a riboswitch found primarily in Gram-positive bacteria which monitors the aminoacylation of the cognate tRNA and regulates a variety of amino acid-related genes. Novel 4,5-disubstituted oxazolidinones were identified as high affinity RNA molecular effectors that modulate the transcription antitermination function of the T box riboswitch.