Rat odontoblasts may use glutamate to signal dentin injury
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- 作者：Yi Sul Choa ; &dagger ; ; Chang Hyun Ryua ; &dagger ; ; Jong Hwa Wonb ; Hue Vangb ; Seog Bae Ohb ; Jin Young Roc ; Yong Chul Baea ; ycbae@knu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATP ; Adenosine triphosphate ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; EM ; electron microscopic ; FBS ; fetal bovine serum ; GluR ; glutamate receptor ; HSA ; human serum albumin ; LM ; light microscopic ; mGluR5 ; metabotropic glutamate receptor 5 ; NDS ; normal donkey serum ; NF200 ; neurofilament 200 ; NMDA receptor ; N-methyl-d-aspartate receptor ; PB ; phosphate buffer ; PBS ; phosphate-buffered saline ; PFA ; paraformaldehyde ; TBST ; tris-buffered saline containing 0.1% triton X-100 ; TH ; tyrosine hyd
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：29 October 2016
- 年：2016
- 卷：335
- 期：Complete
- 页码：54-63
- 全文大小：3787 K
文摘
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Odontoblasts were enriched with glutamate, at the level as high as in adjacent pulpal axons.
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Glutamate level in odontoblasts and mGluR5 expression in adjacent axons were increased following dentin injury.
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Application of calcium ionophore induced glutamate release from cultured odontoblasts.
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These findings suggest that odontoblast may release glutamate as a neuroactive substance.
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