Immunohistochemical analysis of huntingtin-associated protein 1 in adult rat spinal cord and its regional relationship with androgen receptor

详细信息    查看全文

• 作者：Md. Nabiul Islam ; Yukio Takeshita ; Akie Yanai ; Amami Imagawa ; Mir Rubayet Jahan ; Greggory Wroblewski ; Joe Nemoto ; Ryutaro Fujinaga ; Koh Shinoda ; ^{shinoda@yamaguchi-u.ac.jp}
• 关键词：ALS ; amyotrophic lateral sclerosis ; AR ; androgen receptor ; BDNF ; brain-derived neurotrophic factor ; CGRP ; calcitonin gene-related peptide ; ChAT ; choline acetyltransferase ; DAB ; diaminobenzidine ; DLN ; dorsal nucleus ; ENK ; enkephalin ; GFAP ; glial fibrillary acidic protein ; HAP1 ; huntingtin-associated protein 1 ; Htt ; Huntingtin ; Iba-1 ; ionized calcium-binding adapter molecule 1 ; ICL ; intercalated nucleus ; IML ; intermediolateral nucleus ; ir ; immunoreactive ; KO ; knockout ; LDCom ; lumbar dorsal commiss
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：201-217
• 全文大小：7545 K
• 卷排序：340

文摘

HAP1 is abundantly expressed in spinal neurons of the somatosensory, viscerosensory and autonomic regions. More than 80% of neurons expressed both HAP1 and androgen receptor (AR) in the dorsal horn and around the central canal. HAP1 was completely lacking in the spinal motoneurons with or without AR expression. Due to lack of putative HAP1 protectivity, motoneurons might be more vulnerable to stresses in neurodegenerative diseases.