Chlorpyrifos- and chlorpyrifos oxon-induced neurite retraction in pre-differentiated N2a cells is associated with transient hyperphosphorylation of neurofilament heavy chain and ERK 1/2
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- 作者：Ramya A. Sindia ; c ; ramya.sindi2010@my.ntu.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Wayne Harrisa ; Gordon Arnottb ; John Flaskosd ; Chris Lloyd Millsb ; Alan J. Hargreavesa ; alan.hargreaves@ntu.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chlorpyrifos ; Organophosphate toxicity ; Neurite outgrowth ; Mouse N2a neuroblastoma cells ; Neurofilaments ; Microtubules ; Neurotoxicity
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：308
- 期：Complete
- 页码：20-31
- 全文大小：1908 K
文摘
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Chlorpyrifos and chlorpyrifos oxon induced rapid neurite retraction in N2a cells.
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This occurred following transient hyperphosphorylation of ERK 1/2.
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It was concomitant with hyperphosphorylation of neurofilament heavy chain (NFH).
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Subsequent NFH dephosphorylation was associated with increased phosphatase activity.
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Thus, the above changes reflect key events in chlorpyrifos induced neurodegeneration.