Increased indoleamine 2,3-dioxygenase activity in type 2 diabetic nephropathy

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• 作者：Yue Zhang ; Yizhe Ruan ; Ping Zhang ; Li Wang ; ^{scwangli62@163.com}
• 关键词：Indoleamine 2 ; 3-dioxygenase ; Type 2 diabetic nephropathy ; Estimated glomerular filtration rate ; Latent glomerulonephritis ; Maintenance hemodialysis
• 刊名：Journal of Diabetes and its Complications
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：223-227
• 全文大小：464 K
• 卷排序：31

文摘

The study aimed to test the hypothesis that indoleamine 2,3-dioxygenase (IDO) plays a pathogenic role in type 2 diabetic nephropathy (DN).MethodsOne hundred individuals were recruited in our study from January 2012 to December 2013, including group A (control group, 24 healthy adults), group B (20 patients with latent glomerulonephritis), group C (32 type 2 DN patients, estimated glomerular filtration rate (eGFR) > 30 ml/min per 1.73 m2), group D (24 maintenance hemodialysis, MHD patients). Clinical parameters such as gender, age, urine samples, serum creatinine, eGFR, L-tryptophan, L-kynurenine and 24 h urinary protein were collected and analyzed. Group C was further divided on C1 (eGFR > 60 ml/min per 1.73 m2) and C2 (eGFR 31–60 ml/min per 1.73 m2).ResultsAge was not related to IDO activity (r = 0.27, P = 0.057), while eGFR was significantly related to IDO activity (r = − 0.54, P = 0.002). IDO activity was significantly higher in the group C1 than group A (P = 0.003), group B (P = 0.008), and lower than in group D (P = 0.003).ConclusionsIDO activity increased with severity of chronic kidney disease and negatively correlated with eGFR. Moreover, IDO activity was significantly increased in type 2 DN when eGFR was > 60 ml/min per 1.73 m2, which suggested that IDO may closely correlate with the pathogenesis of type 2 DN.