The MLN4924 inhibitor exerts a neuroprotective effect against oxidative stress injury via Nrf2 protein accumulation
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- 作者：Ana Cristina Andé ; rica-Romeroa ; Jacqueline Herná ; ndez-Damiá ; na ; Gustavo Ignacio Vá ; zquez-Cervantesa ; Ismael Torresb ; José ; Pedraza-Chaverria ; pedraza@unam.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：CGNs ; Cerebellar granule neurons ; Cul3 ; Cullin 3 ; DHE ; Dihydroethidium ; DIV ; Days in vitro ; FBS ; Fetal bovine serum ; FDA ; Fluorescein diacetate ; H2O2 ; Hydrogen deroxide ; MLN4924 ; Selective inhibitor of NAE ; MTT ; 3-[4 ; 5-dimethylthiazol-2-yl)]-2 ; 5-diphenyl-tetrazolium bromide ; NAE ; Nedd8-activating enzyme ; Nedd8 ; Neural precursor cell expressed developmentally down-regulated protein 8 ; Nrf2 ; Nuclear factor E2-related factor 2 ; PCNA ; Proliferating cell nuclear antigen ; ROS ; Reactive oxygen species
- 刊名：Redox Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：8
- 期：Complete
- 页码：341-347
- 全文大小：1678 K
文摘
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MLN4924 attenuates H2O2-induced neuronal damage.
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MLN4924 attenuates H2O2-induced ROS production in neurons.
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MLN4924 promotes both nuclear and cytoplasmic accumulation of Nrf2.