• 作者：J. Raú ; l Olmos-Zuñ ; iga^a ; ^{raolzu@yahoo.com} ; Ignacio Dorantes-Mancebo del Castillo^b ; Arturo Avila-Chá ; vez^b ; Rogelio Jasso-Victoria^a ; Miguel Gaxiola-Gaxiola^c ; Avelina Sotres-Vega^a ; Claudia Herná ; ndez-Jim&#233 ; nez^a ; Arturo Ramí ; rez-Garcí ; a^b ; Patricio Santillan-Doherty^d
• 关键词：Pericardio bovino ; Glutaraldehí ; do ; Liofilizació ; n ; Medializació ; n ; Cuerdas vocales ; Absorció ; n ; Migració ; n ; Extrusió ; n
• 刊名：Acta Otorrinolaringol¨®gica Espa?ola
• 出版年：2013
• 出版时间：January-February, 2013
• 年：2013
• 卷：64
• 期：1
• 页码：37-44
• 全文大小：1458 K

Introduction

Glutaraldehyde-preserved bovine pericardium (GBP) and lyophilized GBP (LGBP) have been used successfully in repairing several anatomical defects, but their effectiveness and safety as implants to vocal cords (VC) have not been reported.

Objective

The aim of this study was to evaluate the use of GBP and LGBP as materials for medialization thyroplasty, as well as to assess the endoscopic, macroscopic and microscopic VC changes after medialization in an experimental canine model.

Material and methods

In 12 healthy mongrel dogs, the right VC were medialized using pericardium and the left with polytetrafluoroethylene (PTFE). Group 1 (n = 6): GBP and Group 2 (n = 6): LGBP. The surgical manoeuvrability of the implants was compared. The animals were evaluated clinically and endoscopically. Three months after surgery, the larynges were assessed macro- and microscopically.

Results

Both GBP and LGBP implants showed better surgical manoeuvrability (Kruskal-Wallis, P = .005). Endoscopic and macroscopic studies showed no evidence of granulomas, absorption or extrusion of the implant. At the end of the study, greater thickness was observed in VC implanted with PTFE. Microscopically, all the VC developed fibrous capsules surrounding the implants and similar chronic inflammation reaction. The VC implanted with PTFE presented eosinophilic infiltration (Kruskal-Wallis, P < .05).

Conclusion

Both GBP and LGBP can be used as implants for VC medialization because they are biocompatible, have easy surgical manoeuvrability, do not suffer absorption, migration or extrusion and produce inflammation reactions similar to those of PTFE.