Simultaneous determination of moxifloxacin and ofloxacin in physiological fluids using high performance liquid chromatography with ultraviolet detection
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- 作者：Fahim Ullah Khan ; Fazli Nasir ; fazlinasir@upesh.edu.pk" class="auth_mail" title="E-mail the corresponding author ; Zafar Iqbal ; Ismail Khan ; Naila Shahbaz ; Muhammad Hassan ; Farhad Ullah
- 关键词：HPLC&ndash ; UV ; Moxifloxacin ; Ofloxacin
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：1017-1018
- 期：Complete
- 页码：120-128
- 全文大小：1933 K
文摘
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Simultaneous determination of moxifloxacin and ofloxacin in physiological fluids using HPLC–UV detection is carried out for the first time.
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This method is more sensitive compared to reported methods.
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This method is applicable for analysis of both drugs in plasma, aqueous humor and pharmaceutical dosage forms.
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Extraction is carried out using simple protein precipitation method.