Repetitive stent thrombosis in a patient who had resistance to both clopidogrel and prasugrel

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• 作者：Yuji Ohno ; MD ; ^{yuji.o.chiba@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sho Okada ; MD ; PhD ; Hideki Kitahara ; MD ; PhD ; Takeshi Nishi ; MD ; Takashi Nakayama ; MD ; PhD ; Yoshihide Fujimoto ; MD ; Yoshio Kobayashi ; MD ; FJCC
• 关键词：Prasugrel resistance ; Clopidogrel resistance ; Stent thrombosis ; Platelet function test
• 刊名：Journal of Cardiology Cases
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：13
• 期：5
• 页码：139-142
• 全文大小：695 K

文摘

Clopidogrel resistance is associated with stent thrombosis. Prasugrel achieves greater platelet inhibition with less variability among patients than does clopidogrel. Thus, a patient who had stent thrombosis due to clopidogrel resistance may receive prasugrel to prevent repeated episodes of stent thrombosis. This case report describes a case of repetitive stent thrombosis in which resistance not only to clopidogrel, but also to prasugrel, was observed.

<Learning objective: In the face of clopidogrel resistance, prescribing prasugrel may be an acceptable treatment option. However, cross-unresponsiveness may be observed between clopidogrel and prasugrel. Thus, platelet function assay should be performed in patients with stent thrombosis, even when clopidogrel is replaced with prasugrel.>