Myeloid differentiation protein 2-dependent mechanisms in retinal ischemia-reperfusion injury

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• 作者：Luqing Ren^a ; Jianjian Tao^a ; ^b ; Huaicheng Chen^a ; ^b ; Yang Bian^a ; ^b ; Xi Yang^a ; ^b ; Gaozhi Chen^a ; Xin Zhang^a ; Guang Liang^a ; Wencan Wu^b ; ^{wuwencan118@163.com} ; Zongming Song^b ; ^{szmeyes@126.com} ; Yi Wang^a ; ^{yi.wang1122@wmu.edu.cn}
• 关键词：MD2 ; TLR4 ; HMGB-1 ; Inflammation ; Apoptosis ; Retinal ischemia-reperfusion injury
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：317
• 期：Complete
• 页码：1-11
• 全文大小：1752 K
• 卷排序：317

文摘

MD2 inhibition reduced retinal damage after I/R induction in mice. TBHP induced TLR4/MD2 binding via increasing HMGB-1 expression. TLR4/MD2 initiated inflammatory response via activation of MAPKs and NF-κB. MD2 could be the therapeutic target for the treatment of retinal I/R.