Modeling of suspended vs. immobilized whole-cell amperometric biosensors
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- 作者：Tal Yoetz-Kopelman1 ; aAuthor Vitae ; Richa Pandey1 ; a ; rp6801@gmail.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Amihay FreemanbAuthor Vitae ; Yosi Shacham-DiamandaAuthor Vitae
- 关键词：Modeling ; Whole-cell biosensor ; Electrochemical biosensor ; COMSOL multiphysics&trade ; simulation ; Immobilization ; Chronoamperometry
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：238
- 期：Complete
- 页码：1248-1257
- 全文大小：2428 K
文摘
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Modelling and results of two whole-cell biosensor architectures are presented.
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Cells are bacteria expressing intracellular enzyme generating an electroactive product.
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The effect of cells distribution, suspended or immobilized, was analysed.
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Placing bacteria closer to electrode's surface shorten measurement time.
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The 1D model validated the experimental results.