A targeted drug delivery system based on dopamine functionalized nano graphene oxide

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• 作者：Elham Masoudipour^a ; Soheila Kashanian^b ; ^c ; ^{kashanian_s@yahoo.com} ; Nasim Maleki^d
• 关键词：nGO ; nano graphene oxide ; DA ; dopamine ; MTX ; Methotrexate ; EPR ; enhanced permeation and retention ; EDC ; N-(3-dimethylaminopropyl-N-ethylcarbodiimide) hydrochloride ; NHS ; N-hydroxysuccinimide ; FT-IR ; Fourier transform infrared ; AFM ; atomic force microscopy ; FE-SEM ; field emission scanning electron microscopy ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyl tetrazolium bromide ; DLC ; drug loading content ; DLE ; drug loading efficiency ; DMEM ; Dulbecco's modified eagle medium ; FBS ; fetal bovine serum
• 刊名：Chemical Physics Letters
• 出版年：2017
• 出版时间：16 January 2017
• 年：2017
• 卷：668
• 期：Complete
• 页码：56-63
• 全文大小：1798 K
• 卷排序：668

文摘

Dopamine receptors can be employed for specific targeting of cancer cells. Dopamine conjugated nano graphene oxide acts as a nanocarrier of drug delivery. The release profile of methotrexate from this nanocarrier is diffusion-controlled.