Mesenchymal stem cells overexpressing IL-35 effectively inhibit CD4⁺ T cell function

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• 作者：Na Zhao ; ¹ ; ^{nasy3367@126.com} ; Hongyue Li¹ ; Yongjia Yan ; Ruoyu Jiang ; Xianghui He
• 关键词：Ad-MSCs ; adipose derived mesenchymal stem cells ; IL-35 ; Interleukin-35 ; Tregs ; regulatory T cells ; MOI ; multiplicity of infection ; GFP ; green fluorescent protein
• 刊名：Cellular Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：312
• 期：Complete
• 页码：61-66
• 全文大小：1591 K
• 卷排序：312

文摘

IL-35 gene modified MSCs were constructed by lentivirus transfection and can produce large amounts of IL-35 in vitro. IL-35-MSCs can inhibit the proliferation of CD4+ T cells and IL-17A secretion. IL-35-MSCs also can induce IL-10 production by CD4+ T cells, but did not affect IFN-γ. IL-35-MSCs can increase the proportion of CD4+Foxp3+Treg cells.