Intensive PM2.5 and CO monitoring was performed in 12 biomass fuel-using households in Janakpur. Domestic cooking activity patterns and kitchen, stove and fuel characteristics were recorded. Temporal PM2.5 and CO patterns demonstrated diurnal variability reflecting morning and evening cooking sessions. Average PM2.5 and peak CO concentrations both exceeded World Health Organization (WHO) Indoor Air Quality Guidelines. Concentrations of PM2.5 and CO were moderately correlated during cooking periods.