Lack of association between MPC2 variants and schizophrenia in a replication study of Han Chinese

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• 作者：Chunhui Jin ; Yunbiao Zhang ; Jidong Wang ; Zhenhe Zhou ; Weiwei Sha ; Mingzhong Wang ; Fuquan Zhang ; Jijiang Li ; Jianfeng Li ; Shui Yu ; Shuguang Qi ; Jianmin Yuan
• 关键词：Schizophrenia ; Mitochondrial pyruvate carrier 2 ; Single nucleotide polymorphism ; Allele ; Han Chinese
• 刊名：Neuroscience Letters
• 出版年：2013
• 出版时间：27 September, 2013
• 年：2013
• 卷：552
• 期：Complete
• 页码：120-123
• 全文大小：471 K

文摘

Schizophrenia (SCZ) is a common, complex and severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified a single-nucleotide polymorphism (SNP, rs10489202) in the mitochondrial pyruvate carrier 2 gene (MPC2, also known as BRP44) as a possible susceptibility locus for schizophrenia. Hoping to validate this finding, we conducted a case-control study of Han Chinese with 1093 schizophrenia cases and 1022 healthy controls, using the LDR-PCR method to genotype polymorphisms (rs10489202 and a TagSNP rs203861) in the MPC2 gene. However, we found no significant difference (P > 0.05) in either allele or genotype frequency in the SNPs between patients and controls. These results did not support the previous finding suggesting the further study by using a large-scale association analysis in the future should be warranted in Han Chinese populations.