Transient decrease in cerebral motor pathway fractional anisotropy after focal ischemic stroke in monkey

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• 作者：Yo Chin ; Yuki Sato ; Mitsuhito Mase ; Tomomasa Kato ; Bruno Herculano ; Masaki Sekino ; Hiroyuki Ohsaki ; Naohide Ageyama ; Fumiko Ono ; Keiji Terao ; Yasuhiro Yoshikawa ; Tatsuhiro Hisatsune
• 关键词：Cerebral motor pathway ; Diffusion MRI ; Functional recovery ; Ischemic injuries ; Monkey ; White matter
• 刊名：Neuroscience Research
• 出版年：2010
• 出版时间：April 2010
• 年：2010
• 卷：66
• 期：4
• 页码：406-411
• 全文大小：1377 K

文摘

In this study, diffusion tensor MRI was used to examine the restoration of the cerebral white matter of macaque monkeys after unilateral cerebral multiple microinfarctions. Post-stroke, the monkeys showed deficits in several neurological functions, including motor functions, but most of the deficits resolved within 6 weeks. Very interestingly, the fractional anisotropy (a value determined by diffusion tensor MRI), of the monkeys’ affected motor pathways dropped transiently, indicating a damage in the neural tracts. However, it returned to normal levels within 6 weeks after the stroke, concomitant with the gradual recovery of motor functions at subacute phase.