Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson’s disease

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• 作者：Michael D. Boska ; Khader M. Hasan ; Danette Kibuule ; Rebecca Banerjee ; Erin McIntyre ; Jay A. Nelson ; Theresa Hahn ; Howard E. Gendelman ; R. Lee Mosley
• 关键词：Parkinson’ ; s disease ; Diffusion tensor imaging ; 1-Methyl-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; MPTP ; Substantia nigra ; Striatum ; Dopaminergic neurons
• 刊名：Neurobiology of Disease
• 出版年：2007
• 出版时间：June 2007
• 年：2007
• 卷：26
• 期：3
• 页码：590-596
• 全文大小：626 K

文摘

Early diagnosis of Parkinson’s disease (PD) is required to improve therapeutic responses. Indeed, a clinical diagnosis of resting tremor, rigidity, movement and postural deficiencies usually reflect > 50 % loss of the nigrostriatal system in disease. In a step to address this, quantitative diffusion tensor magnetic resonance imaging (DTI) was used to assess nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication model of dopaminergic nigral degeneration. We now demonstrate increased average diffusion (p < 0.005) and decreased fractional anisotropy (p < 0.03) in the substantia nigra (SN) of 5- to 7-day MPTP-treated animals when compared to saline controls. Transverse diffusivity demonstrated the most significant differences (p ≤ 0.002) and correlated with the numbers of SN dopaminergic neurons (r = − 0.75, p = 0.012). No differences were found in the striatum, corpus callosum, cerebral cortex, or ventricles. These results demonstrate that DTI may be used as a surrogate biomarker of nigral dopaminergic neuronal degeneration.