Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells
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- 作者：Catherine E. Mossa ; Leslie L. Glassa ; Eleftheria Diakogiannakia ; Ramona Paisa ; Carol Lenaghanb ; David M. Smithc ; Marianne Wedind ; Mohammad Bohlooly-Yd ; Fiona M. Gribblea ; fmg23@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Frank Reimanna ; fr222@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-OG ; 2-oleoylglycerol ; Fsk ; forskolin ; GLP-1 ; glucagon-like peptide-1 ; IBMX ; 3-isobutyl-1-methylxanthine ; KO ; knockout ; OEA ; oleoylethanolamide ; PPAR ; peroxisome-proliferator-activated receptor ; WT ; wildtype
- 刊名：Peptides
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：16-20
- 全文大小：443 K
文摘
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GPR119, a putative fat sensor, is a potential target for metabolic disease.
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10">KO of GPR119 in murine L-cells reduced GLP-1 response to fat in vivo.
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15">Primary L-cells secreted GLP-1 in response to GPR119 agonists.
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GPR119 agonists increased L-cell cAMP, with greatest efficacy in the colon.
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Our data support the use of GPR119 agonists to raise GLP-1 levels.
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