Regulation of early expression of Dlx3, a Xenopus anti-neural factor, by β-catenin signaling

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• 作者：Beanan ; Maureen J. ; Feledy ; Jules A. ; Sargent ; Thomas D.
• 关键词：Early expression ; Dlx3 ; Xenopus anti-neural factor ; β ; -Catenin signaling
• 刊名：Mechanisms of Development
• 出版年：2000
• 出版时间：March 1, 2000
• 年：2000
• 卷：91
• 期：1-2
• 页码：227-235
• 全文大小：1.38 M

文摘

The ectoderm of the pre-gastrula Xenopus embryo has previously been shown to be at least partially patterned along the dorsal-ventral axis. The early expression of the anti-neural homeodomain gene Dlx3 is localized to the ventral ectoderm by a mechanism that occurs prior to gastrulation and is independent of the Spemann organizer. The repression of Dlx3 is mediated by signaling though β-catenin, but is probably not dependent on the induction of the Xnr3 or chordin genes by β-catenin. We propose a model in which this early regulation of Dlx3 accounts for the pro-neural bias of dorsal ectoderm.