Inhibitory control of ascending glutamatergic projections to the lamprey respiratory rhythm generator
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- 作者：Elenia Cinelli ; Donatella Mutolo ; Massimo Contini ; Tito Pantaleo ; Fulvia Bongianni ; fulvia.bongianni@unifi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：I1 ; isthmic Mü ; ller cell ; MRRN ; middle rhombencephalic reticular nucleus ; NOMI ; intermediate octavomotor nucleus ; NOMP ; posterior octavomotor nucleus ; NTS ; nucleus tractus solitarii ; nVm ; motor root of the trigeminal nerve ; nVs ; sensory root of the trigeminal nerve ; nVIII ; vestibular nerve ; nIX ; glossopharyngeal nerve ; nX ; vagal nerve ; OLA ; octavolateral area ; PB ; phosphate buffer ; PBS ; phosphate-buffered saline ; PRRN ; posterior rhombencephalic reticular nucleus ; pTRG ; paratrigeminal respira
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：21 June 2016
- 年：2016
- 卷：326
- 期：Complete
- 页码：126-140
- 全文大小：3024 K
文摘
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We found neurons projecting to the pTRG in vagal, glossopharyngeal and facial motor regions as well as in the sensory OLA.
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Projecting neurons are glutamatergic, surrounded by GABA-immunoreactive structures and associated with glycinergic cells.
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Blockade of GABAA and glycine receptors within these regions increases the respiratory frequency.
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The results indicate that disinhibition can be one important mechanism subserving ascending pathway activation.
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Projecting neurons are possibly involved in sensory-mediated respiratory regulation.