Sympathetic Hyperactivity and Aortic Sympathetic Nerve Sprouting in Patients with Thoracic Aortic Dissection

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• 作者：Hu Zhipeng¹ ; ^&lowast ; ; Wang Zhiwei¹ ; ^&lowast ; ; ^{wangzhiwp@gmail.com" class="auth_mail} ; Yu Lilei² ; Zhang Hao¹ ; Wu Hongbing¹ ; Ren Zongli¹ ; Chen Hao¹ ; Hu Xiaoping¹
• 刊名：Annals of Vascular Surgery
• 出版年：July 2014
• 年：2014
• 卷：28
• 期：5
• 页码：1243-1248
• 全文大小：784 K

文摘

To determine the yet unknown relation between thoracic aortic dissection (TAD) and sympathetic nervous system activity.

Methods

Variables such as electrocardiography, blood pressure, respiratory activity, postganglionic muscle sympathetic nerve activity 锛圡SNA锛? plasma norepinephrine, tyrosine hydroxylase–positive nerve fiber density, and growth-associated protein 43–positive nerve fiber density were detected and statistically analyzed.

Results

TAD Patients showed a significant lower R-R interval variance and higher blood pressure, heart rate, respiratory rate, MSNA, plasma norepinephrine (reflecting elevated sympathetic nervous system [SNS] activity), higher tyrosine hydroxylase, growth-associated protein 43–positive nerve fiber density (reflecting sympathetic sprouting and innervation) than those of the control group.

Conclusions

In TAD patients, both overall and regional aortic SNS activities are elevated.