- 作者：Jin-bo Ma ; Ph.D. ; M.D.&lowast ; ; &Dagger ; ; Yi-peng Song ; Ph.D. ; M.D.&lowast ; ; &Dagger ; ; Jin-ming Yu ; Ph.D. ; M.D.&lowast ; ; &dagger ; ; yujmwin@yahoo.cn ; Wei Zhou ; Ph.D. ; M.D.&lowast ; ; Er-cheng Cheng ; M.D.&Dagger ; ; Xi-qin Zhang ; M.D.&dagger ;
- 关键词：[18F]FDG-PET ; Esophageal cancer ; Late-course accelerated hyperfractionated irradiation ; Linear correlation
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2012
- 出版时间：15 March, 2012
- 年：2012
- 卷：82
- 期：4
- 页码：1535-1540
- 全文大小：223 K
Purpose
The aims of this trial were to study whether a decreased percentage of tumor fluorodeoxyglucose (FDG) uptake ( % DeltaSUVmax) correlated with overall survival and local control times for patients with esophageal cancer and which patients would benefit from a late-course accelerated hyperfractionated (LCHF) radiation scheme.Methods and Materials
A total of 50 eligible patients with squamous esophageal cancer received positron-emission tomography examinations three times and were treated with the LCHF radiation scheme, with a dose of 68.4 Gy/41 fractions in 6.5 weeks. A % DeltaSUVmax value was calculated, and patients were stratified as highly radiosensitive (HR), moderately radiosensitive (MR), and low radiosensitivity (LR) according to % DeltaSUVmax values in the conventional fraction (CF) scheme. Then, a linear correlation was calculated between patients?survival time and % DeltaSUVmax. Local control and overall survival rates were compared after stratification.
Results
In the MR subgroup, there was no linear correlation between % DeltaSUVmax and the CF and LCHF schemes (correlation coefficient, R < 0.4; p > 0.05). In the other subgroups (HR and LR), % DeltaSUVmax values between the CF and LCHF schemes were correlated. Also, in the HR and LR subgroups, % DeltaSUVmax after radiation correlated with overall survival or local control rates (correlation coefficient, R ?.5, and p < 0.05). Three-year local control rates in the HR, MR, and LR subgroups were 100 % , 81.5 % , and 0 % , respectively (p < 0.001). Also, 3-year overall survival rates were 92.4 % , 58.8 % , and 0 % for HR, MR, and LR subgroups, respectively (p < 0.001).
Conclusions
Postradiation % DeltaSUVmax was positively correlated with survival time for patients?with esophageal cancer. Patients who benefited from LCHF schedules were those with a decrease of 30 % to 60 % in tumor FDG uptake after the completion of CF radiation.