Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress
详细信息 查看全文
- 作者：Yingying Liu1 ; Shanshan Fang1 ; Qiushi Sun ; sunqiushi0801@163.com" class="auth_mail" title="E-mail the corresponding author ; Bo Liu ; liubo8810@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ivermectin ; Angiogenesis ; Mitochondrial functions ; Akt/mTOR ; Glioblastoma
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：18 November 2016
- 年：2016
- 卷：480
- 期：3
- 页码：415-421
- 全文大小：1188 K
文摘
- •
Ivermectin is effective in glioblastoma cells in vitro and in vivo.
- •
Ivermectin inhibits angiogenesis.
- •
Ivermectin induces mitochondrial dysfunction and oxidative stress.
- •
Ivermectin deactivates Akt/mTOR signaling pathway.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |