Mechanisms and metabolic regulation of PPARα activation in Nile tilapia (Oreochromis niloticus)
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- 作者：Li-Jun Ning1 ; An-Yuan He1 ; Jia-Min Li ; Dong-Liang Lu ; Jian-Gang Jiao ; Ling-Yu Li ; Dong-Liang Li ; Mei-Ling Zhang ; Li-Qiao Chen ; Zhen-Yu Du ; zydu@bio.ecnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nile tilapia ; PPARα activation ; Dephosphorylation ; Fenofibrate ; Fasting ; Metabolism
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1861
- 期：9
- 页码：1036-1048
- 全文大小：2303 K
文摘
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PPARα was activated in response to fenofibrate and fasting in Nile tilapia.
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Liver is one of the main target tissues of NtPPARα activation.
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Dephosphorylation is the basal mechanism of NtPPARα activation.
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NtPPARα activation increased activity and the number of hepatic mitochondria.
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PPARα activation affects carbohydrate metabolism.