- 作者：Lingyun Cheng ; Alay S. Banker ; Michael Martin ; Igor Kozak ; William R. Freeman
- 刊名：Ophthalmology
- 出版年：2009
- 出版时间：July 2009
- 年：2009
- 卷：116
- 期：7
- 页码：1356-1359
- 全文大小：314 K
Purpose
To characterize the concentration–time profile of triamcinolone acetonide (TA) in human aqueous after a single, 20-mg, intravitreal injection.Design
Case series.
Participants
Seven patients and 10 eyes that received intravitreal injection of the decanted 20 mg of TA.
Methods
Fifty microliters of aqueous were sampled from each intravitreally TA-injected eye at postinjection monthly interval and the samples were subjected to liquid chromatography coupled with tandem mass spectrometric detection for TA.
Main Outcome Measures
The TA concentration in the aqueous.
Results
The TA was cleared from the aqueous in a monoexponential manner with a half-life of 29.6 days and clearance coefficient of 0.0234 (1/day). The extrapolated maximum TA concentration in aqueous was about 3312 ng/ml and the area under the curve was 74 017 day × ng/ml.
Conclusions
The TA concentration in human aqueous could stay above therapeutic concentration for 150 days (5 half-lives with remaining TA concentration of 104 ng/ml) after a 20-mg intravitreal injection, suggesting an even longer therapeutic concentration of TA in vitreous.
Financial Disclosure(s)
The authors have no proprietary or commercial interest in any of the materials discussed in this article.