Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist

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• 作者：Erika Pellegrini¹ ; ² ; André ; s Palencia³ ; Laurence Braun³ ; Ulrike Kapp⁴ ; Alexandre Bougdour³ ; Hassan Belrhali¹ ; ² ; ^{belrhali@embl.fr} ; Matthew W. Bowler¹ ; ² ; ^{mbowler@embl.fr} ; Mohamed-Ali Hakimi³ ; ⁵ ; ^{mohamed-ali.hakimi@univ-grenoble-alpes.fr}
• 关键词：GRA24 ; MAPK p38 ; Toxoplasma effector ; immunity ; intrinsically disordered protein
• 刊名：Structure
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：16-26
• 全文大小：2996 K
• 卷排序：25

文摘

Toxoplasmosis controls its host immune response via a protein effector, GRA24 A recombinant complex of GRA24 and MAPK p38α demonstrates how the protein works An adapted KIM domain ensures activation and a sustained inflammatory response The recombinant complex is useful in the evaluation of p38 inhibitors