Tumor microenvironment-responsive charge reversal zinc phthalocyanines based on amino acids for photodynamic therapy
详细信息 查看全文
- 作者：Ao Wang1 ; Li Gui1 ; Shan Lu ; Lin Zhou ; zhoulin@njnu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jiahong Zhou ; Shaohua Wei ; shwei@njnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Charge reversal ; Zinc phthalocyanines ; Amino acids ; Photodynamic therapy ; Tumor microenvironment ; Isoelectric pH
- 刊名：Dyes and Pigments
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：126
- 期：Complete
- 页码：239-250
- 全文大小：1750 K
文摘
- •
Charge reversible zinc phthalocyanines substituted with amino acids were prepared.
- •
The isoelectric pHs and charge reversal sensitivity of AAZnPcs were regulated.
- •
The charge of AAZnPcs can be responsive to tumor microenvironment.
- •
Charge reversible GluZnPc and OGluZnPc showed enhanced photodynamic activities.
- •
GluZnPc and OGluZnPc are promising photosensitizers for photodynamic therapy.