Cytokine-induced memory-like NK cell differentiation enhances NK cell responses. Memory-like differentiation augments licensed and unlicensed NK cell function. Unlicensed NK cell antitumor responses are restored via memory-like differentiation. FcγRIIIa stimulates enhanced IFN-γ production and killing by memory-like NK cells. Mechanisms of memory-like functionality are distinct from human cytomegalovirus–adapted NK cells.