Has the symptom severity inclusion requirement narrowed the definition of major depressive disorder in antidepressant efficacy trials?
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- 作者：Mark Zimmerman ; mzimmerman@lifespan.org ; Emily Walsh ; Iwona Chelminski ; Kristy Dalrymple
- 关键词：Depression ; Severity ; Hamilton Depression Rating Scale ; Generalizability ; Inclusion criteria ; Antidepressant efficacy trial
- 刊名：Journal of Affective Disorders
- 出版年：2017
- 出版时间：15 March 2017
- 年：2017
- 卷：211
- 期：Complete
- 页码：60-64
- 全文大小：183 K
- 卷排序：211
文摘
Placebo-controlled studies of antidepressants require a minimum level of severity on standardized measures such as the HAMD. The number of DSM-5 MDD symptom criteria met is significantly associated with HAMD scores. Thus, placebo-controlled studies of antidepressants require more DSM-IV/DSM-5 symptom criteria than are required for the diagnosis.