The interaction of dietary isoflavones and estradiol replacement on behavior and brain-derived neurotrophic factor in the ovariectomized rat

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• 作者：Ashley L. Russell^a ; ^b ; ¹ ; Jamie Moran Grimes^a ; ^c ; ¹ ; Darwin O. Larco^b ; Danette F. Cruthirds^c ; Joanna Westerfield^d ; Lawren Wooten^c ; Margaret Keil^c ; Michael J. Weiser^e ; Michael R. Landauer^d ; Robert J. Handa^e ; T. John Wu^a ; ^b ; ^c ; ^{tao-yiao.wu@usuhs.edu}
• 关键词：Isoflavones ; 17β-estradiol ; Anxiety ; Depression ; BDNF
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：640
• 期：Complete
• 页码：53-59
• 全文大小：848 K
• 卷排序：640

文摘

E2 administration resulted in anxiogenic behaviors when dietary isoflavones were present. E2 administration resulted in anxiolytic and anti-depressive like behaviors when dietary isoflavones were not present. BDNF expression increased after E2 administration when animals were fed an isoflavone-rich diet. BDNF expression in the amygdala and hypothalamus was increased after E2 treatment in animals fed an isoflavone-rich diet.