Human self-generated thought can best be understood by combining multiple methods.
We review key evidence from lesion studies, intracranial EEG, and neuro chemistry.
Intracranial EEG suggests a key role for medial temporal lobe in thought generation.
Medial prefrontal cortex and inferior parietal lobule also appear to be critical.
Self-generated thought is linked to hormones and biomolecules throughout the body.