Hepatitis B virus reactivation after treatment for hepatitis C in hemodialysis patients with HBV/HCV coinfection

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• 作者：Raul Carlos Wahle^a ; ^{wahle@uol.com.br" class="auth_mail" title="E-mail the corresponding author} ; Renata Mello Perez^b ; Patrí ; cia Fucuta Pereira^a ; Elze Maria Gomes Oliveira^a ; Christini Takemi Emori^a ; Silvia Naomi de Oliveira Uehara^a ; Ivonete Sandra de Souza Silva^a ; Antô ; nio Eduardo Benedito Silva^a ; Maria Lucia Gomes Ferraz^a
• 关键词：Coinfection HBV/HCV ; Reactivation HBV ; Hemodialysis
• 刊名：The Brazilian Journal of Infectious Diseases
• 出版年：2015
• 出版时间：September-October 2015
• 年：2015
• 卷：19
• 期：5
• 页码：533-537
• 全文大小：725 K

文摘

In coinfected HBV/HCV patients, HBV replication is usually suppressed by HCV over the time. No study to date has evaluated the HBV viremia in long-term follow-up after HCV treatment in hemodialysis patients with HBV/HCV coinfection. This study aimed to assess the evolution of HBV viremia after HCV treatment in this special population. Ten hemodialysis patients with HBV/HCV coinfection with dominant HCV infection (HBV lower than 2000 IU/mL) and significant fibrosis were treated with interferon-alpha 3 MU 3×/week for 12 months and could be followed for at least 36 months after HCV treatment. Six cases of HBV reactivation (60%) during follow-up were observed and 5/6 had been successfully treated for HCV. Patients with HBV reactivation received anti-HBV therapy. Our preliminary findings indicate that treatment of hepatitis C in HBV/HCV coinfected hemodialysis patients may favor HBV reactivation. Thus, continued monitoring of HBV viremia must be recommended and prompt anti-HBV therapy should be implemented.