Genetic variants of vascular endothelial growth factor are associated with recurrent implantation failure in Korean women

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• 作者：Yong Wook Jung^a ; Jung Oh Kim^b ; HyungChul Rah^b ; Ji Hyang Kim^c ; Young Ran Kim^c ; Yubin Lee^d ; Woo Sik Lee^d ; ^{wooslee@cha.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Nam Keun Kim^b ; ^{nkkim@cha.ac.kr" class="auth_mail" title="E-mail the corresponding author}Author Vitae
• 关键词：female infertility ; genetic association study ; recurrent implantation failure ; single nucleotide polymorphism ; VEGF
• 刊名：Reproductive BioMedicine Online
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：32
• 期：2
• 页码：190-196
• 全文大小：442 K

文摘

Vascular endothelial growth factor (VEGF) is involved in embryonic development, decidual vascularization and placenta angiogenesis. This study was performed to determine whether there is an association between genetic polymorphisms in the VEGF gene and the development of recurrent implantation failure (RIF) in Korean women. A total of 119 women diagnosed with RIF and 236 control subjects were genotyped for VEGF polymorphic sites including rs833061 (-460T>C), rs25648 (-7C>T) and rs3025020 (-583C>T) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays and real-time PCR. The VEGF rs833061 C allele and rs25648 T allele were significantly associated with increased RIF risk (odds ratio [OR] = 1.813 [1.161–2.831], P = 0.009, OR = 2.213 [1.254–3.903], P = 0.005). The rs833061/rs25648 TC/CT, TC/CT+TT, and rs833061/rs3025020 TC+CC/TT genotypes were more frequent in the RIF group compared with the control group (OR = 2.130 [1.092–4.156], P = 0.025, OR = 2.130 [1.092–4.156], OR = 4.261 [1.163–15.620], P = 0.028, respectively). The results of this study suggests that VEGF polymorphisms are associated with RIF development. Therefore, we postulate that VEGF polymorphisms might be useful markers to predict RIF development. Further studies are warranted to elucidate the role of VEGF variants and RIF development.