The chitinases expression is related to Simian Immunodeficiency Virus Encephalitis (SIVE) and in HIV encephalitis (HIVE)

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• 作者：C. Sanfilippo^a ; G. Nunnari^d ; A. Calcagno^e ; L. Malaguarnera^b ; K. Blennow^c ; H. Zetterberg^c ; M. Di Rosa^b ; ^{mdirosa@unict.it}
• 关键词：HIV-1 ; human immunodeficiency virus 1 ; SIV ; simian immunodeficiency virus ; SIVE ; SIV encephalitis ; AIDS ; acquired immune deficiency syndrome ; CHIT1 ; Chitotriosidase ; CHIA ; acidic mammalian chitinase ; CHI3L1 ; BRP-39 ; chitinase 3-like-1 ; CHI3L2 ; chitinase 3-like-2 ; CHID1 ; chitinase domain&ndash ; containing 1 ; CNS ; central nervous system ; CSF ; cerebrospinal fluid ; SMOX ; spermine oxidase ; DCBLD2 ; discoidin ; CUB and LCCL domain containing 2 ; LDLRAD4 ; low density lipoprotein receptor class A domain con
• 刊名：Virus Research
• 出版年：2017
• 出版时间：2 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：220-230
• 全文大小：2948 K
• 卷排序：227

文摘

CHIT1, CHI3L1 and CHI3L2 mRNA levels were significantly increased in HIVE/SIVE hippocampus. Negative correlation was found between CHIA, C1s vs BVL and positive correlation between CHIT1 vs CHI3L2, SLC11A1 and CHI3L2 vs CHID1 and CHID1 vs SLC11A1. Chitinase are potential biomarkers for microglial activation in HIVE/SIVE.