Post-training intracranial self-stimulation facilitates a hippocampus-dependent task
详细信息 查看全文
- 作者：Soriano-Mas ; Carles ; Redolar-Ripoll ; Diego ; Aldavert-Vera ; Laura ; Morgado-Bernal ; Ignacio ; et. al.
- 关键词：Intracranial self-stimulation ; Delayed spatial alternation T-maze task ; Memory facilitation ; Explicit memory ; Flexible expression of memory ; Hippocampus ; Lateral hypothalamus
- 刊名：Behavioural Brain Research
- 出版年：2005
- 出版时间：May 7, 2005
- 年：2005
- 卷：160
- 期：1
- 页码：141-147
- 全文大小：103 K
文摘
Previous research has shown that post-training intracranial self-stimulation facilitates implicit or procedural memory. To know whether it can also facilitate explicit memory, post-training intracranial self-stimulation was given to Wistar rats immediately after every daily session of a delayed spatial alternation task that seems to depend on the integrity of the hippocampal memory system. We tested the effects of intracranial self-stimulation in three consecutive learning phases which tried to make the task progressively more difficult: 10 s delay (D10 phase), 30 s delay (D30 phase), and inverting the starting position of the animals to make their response more dependent on allocentric cues (INV phase). Every phase finished when each rat achieved a fixed learning criterion. Intracranial self-stimulation facilitated the flexible expression of the learned response (INV phase). That is, when the starting position was randomly inverted, only the rats that received intracranial self-stimulation maintained the performance level acquired in the previous training phases. Changing the starting position reduced the correct performance of the non-treated subjects, which need more training sessions to achieve the learning criterion and made less correct responses than treated rats. These findings show that post-training intracranial self-stimulation can facilitate hippocampus-dependent memories.