Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes
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- 作者：Eloi R. Verrier1 ; 2 ; 14 ; Che C. Colpitts1 ; 2 ; 14 ; Charlotte Bach1 ; 2 ; Laura Heydmann1 ; 2 ; Laetitia Zona1 ; 2 ; Fei Xiao1 ; 2 ; Christine Thumann1 ; 2 ; Emilie Crouchet1 ; 2 ; Raphaë ; l Gaudin1 ; 2 ; Camille Sureau3 ; Franç ; ois-Loï ; c Cosset4 ; 5 ; 6 ; 7 ; 8 ; Jane A. McKeating9 ; 10 ; Patrick Pessaux1 ; 2 ; 11 ; Yujin Hoshida12 ; 13 ; Catherine Schuster1 ; 2 ; Mirjam B. Zeisel1 ; 2 ; mirjam.zeisel@unistra.fr" class="auth_mail" title="E-mail the corresponding author ; Thomas F. Baumert1 ; 2 ; 11 ; 15 ; thomas.baumert@unistra.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：NTCP ; hepatitis C virus ; solute carrier ; innate immune responses ; viral entry ; host factor ; signaling ; antiviral therapy ; hepatitis B virus ; hepatitis D virus
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：25 October 2016
- 年：2016
- 卷：17
- 期：5
- 页码：1357-1368
- 全文大小：2888 K
文摘
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NTCP is involved in hepatocyte infection by multiple viruses via distinct mechanisms
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NTCP facilitates HCV infection by modulating innate antiviral responses
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Solute carrier NTCP is a regulator of antiviral immune responses in the liver
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This function is relevant for infection and therapies for hepatotropic viruses
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