Human pegivirus (GB virus C) NS3 protease activity inhibits induction of the type I interferon response and is not inhibited by HCV NS3 protease inhibitors
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- 作者：Adnan Y. Chowdhurya ; b ; chowdhay@slu.edu" class="auth_mail ; John E. Tavisa ; tavisje@slu.edu" class="auth_mail ; Sarah L. Georgea ; b ; c ; georgesl@slu.edu" class="auth_mail
- 关键词：Human pegivirus ; GB Virus-C ; Hepatitis C virus ; MAVS ; TRIF ; Type I interferon ; Serine protease ; Protease inhibitors
- 刊名：Virology
- 出版年：May 2014
- 年：2014
- 卷：456-457
- 期：Complete
- 页码：300-309
- 全文大小：1641 K
文摘
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HPgV protease cleaves MAVS at C508 in cell culture, similar to HCV protease. Neither protease cleaves TRIF in cells.
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HPgV protease inhibits IFN 尾 mRNA production and expression of luciferase from an IFN 尾 promoter reporter in cell culture.
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HPgV protease inhibition of the Type I IFN system increases viral growth in trans.
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20">All these activities of the HPgV protease are abolished if the catalytic serine is mutated to alanine.
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25">Cleavage activity of the HPgV protease is not inhibited by HCV protease inhibitors.