CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1 -SIRT1- PGC-1α activation
详细信息 查看全文
- 作者：Liang Cheng1 ; Bin Li1 ; Xu Chen ; Jie Su ; Hongbing Wang ; Shiqiang Yu ; Qijun Zheng ; qijunzheng123@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CTRP9 ; PGC-1α ; SIRT1 ; Mitochondrial biogenesis ; AdipoR1
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：477
- 期：4
- 页码：685-691
- 全文大小：1255 K
文摘
- •
CTRP9 alleviated ROS production, induced the expression of PGC-1α and SIRT1 in a dose-dependent manner.
- •
CTRP9 induced the mitochondrial biogenesis.
- •
CTRP9 inhibited high glucose induced oxidative stress.
- •
CTRP9 induced the mitochondrial biogenesis through upregulation of PGC-1α and SIRT1 expression.
- •
CTRP9 induced the mitochondrial biogenesis and protected oxidative damage via the activation of AdipoR1.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |