Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase
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- 作者：Xianxun Liu1 ; Yan Zhou1 ; Yuqing Lou ; louyq@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Hua Zhong ; eddiedong8@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HNRNPA1 ; Heterogeneous nuclear ribonucleoprotein A1 ; IκBα ; inhibitory subunit of nuclear factor κ B alpha ; RNAi ; RNA interference ; NSCLC ; non-small cell lung cancer ; TKIs ; tyrosine kinase inhibitors ; NF-κB ; nuclear factor κ B ; shRNA ; short hairpin RNA ; IHC ; immunohistochemistry ; FFPE ; formalin-fixed paraffin-embedded ; HEK293T cell line ; Human embryonic kidney 293 ; T cell line ; FBS ; fetal bovine serum ; GFP ; green fluorescent protein ; scr-shRNA ; scrambled shRNA ; qPCR ; Quantitative real-time po
- 刊名：Gene
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：576
- 期：2
- 页码：791-797
- 全文大小：982 K
文摘
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HNRNPA1 protein overexpressed in lung adenocarcinoma than in adjacent normal tissues.
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The expression of HNRNPA1 in A549 lung cancer cell line was downregulate by shRNA.
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Knockdown of HNRNPA1 inhibited cell viability and colony formation of A549 cell line.
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Downregulation of HNRNPA1 induced cell cycle arrest at G0/G1 phase.
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