sST2 translation is regulated by FGF2 via an hnRNP A1-mediated IRES-dependent mechanism
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- 作者：Michael M. Kunzea ; Fabienne Benza ; Thilo F. Brauß ; a ; Sebastian Lampea ; Julia E. Weigandb ; Johannes Braunb ; Florian M. Richterc ; Ilka Wittigc ; Bernhard Brü ; nea ; Tobias Schmida ; T.Schmid@biochem.uni-frankfurt.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：5&prime ; UTR ; 5&prime ; untranslated region ; CHX ; cycloheximide ; eIF ; eukaryotic initiation factor ; FGF2 ; basic fibroblast growth factor ; hnRNP ; heterogeneous nuclear ribonucleoprotein ; IRES ; internal ribosome entry site ; ITAF ; IRES trans-acting factors ; sST2 ; soluble suppression of tumorigenicity 2
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1859
- 期：7
- 页码：848-859
- 全文大小：1201 K
文摘
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FGF2 induces sST2 translation.
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sST2-5′UTR contains an FGF2-responsive IRES element.
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23 nucleotides within the sST2-5′UTR are required for optimal IRES activity.
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Intact MEK/ERK signaling is required for FGF2-induced sST2-IRES activity.
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hnRNP A1 binds to and activates the sST2-IRES.