• 作者：Peng Chen^a ; ¹ ; Chunyan Zhang^b ; ¹ ; Chen Liu^a ; Liyun Zhang^c ; Chunhe Yang^a ; Guangyu Chen^d ; Dan Ma^c ; Yaping Tian^b ; ^{tianyp61@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Hongwu Du^a ; ^{hwdu93@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：BD ; Behç ; et's disease ; DVT ; deep vein thrombosis ; SLE ; systemic lupus erythematosus ; AECA ; anti-endothelial cell antibodies ; LC&ndash ; TMS ; liquid chromatography tandem mass spectrometry ; PVDF ; polyvinylidene fluoride membranes ; PBS ; Phosphate buffered saline
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：6
• 期：Complete
• 页码：215-221
• 全文大小：1627 K

•

Bioinformatics was used to predict that hnRNP A1 may play a role in BD.

•

HnRNP A1 was immunologically confirmed as an autoantigen of BD.

•

Deep vein thrombosis has a close relationship with anti-hnRNP A1 antibody in patients' blood circulation.

Behçet's disease (BD) is a chronic systemic autoimmune disease. The pathogenesis of BD is still not clear, and the diagnosis is based on typical clinical syndromes. Autoantigen identification was considered a key to solve this problem. This study was to verify the hypothesis suggested by bioinformatics that hnRNP A1 may be a new autoantigen of BD. Among the 720 subjects enrolled and systemic tested, our results demonstrated hnRNP A1 as a new autoantigen of BD, and associated with deep vein thrombosis.