MEDLINE, Embase, trial registries, conference proceedings, and article reference lists were searched to identify trials and/or studies comparing SPUS with pathology or RPUS as the reference standard. Data were abstracted from eligible studies to produce 2 ¡Á 2 contingency tables, permitting the calculation of pooled sensitivity and specificity values.
Eight studies (1,268 patients) evaluated SPUS for appendicitis. For appendicitis, SPUS had a pooled sensitivity of .92 (95 % confidence interval [CI], .887-.939) and a pooled specificity of .96 (95 % CI, .946-.974). SPUS for gallstones was evaluated in 8 studies (1,019 patients). The pooled sensitivity was .96 (95 % CI, .934-.979), and the specificity was .99 (95 % CI .983-.998).
SPUS achieves acceptable sensitivity and specificity for both gallstones and appendicitis. However, there was some evidence of heterogeneity. Data regarding cost-effectiveness are lacking.