The anti-tumor effects of the recombinant toxin protein rLj-RGD3 from Lampetra japonica on pancreatic carcinoma Panc-1 cells in nude mice

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• 作者：Yue Wang^a ; Yuanyuan Zheng^b ; Zuoyu Tu^a ; Yongguo Dai^a ; Hong Xu^a ; Li Lv^a ; ^{lv_li@126.com} ; Jihong Wang^b ; ^{jihongwang999@hotmail.com}
• 关键词：rLj-RGD3 ; Pancreatic carcinoma ; Panc-1 cells ; Anti-tumor ; Mice
• 刊名：Peptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：88
• 期：Complete
• 页码：8-17
• 全文大小：2693 K
• 卷排序：88

文摘

rLj-RGD3 is a new recombinant RGD-toxin protein with 3 RGD motifs and is secreted from the buccal glands of Lampetra japonica. rLj-RGD3 suppresses human pancreatic carcinoma Panc-1 cell-derived tumors in nude mice. rLj-RGD3 exhibits pro-apoptotic effects that are regulated by the intrinsic apoptotic pathway. The effect of rLj-RGD3 on anti-angiogenesis is mediated via the FAK/PI3K/Akt signaling pathway.