TBMS1 exerts its cytotoxicity in NCI-H460 lung cancer cells through nucleolar stress-induced p53/MDM2-dependent mechanism, a quantitative proteomics study
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- 作者：Yingying Lin1 ; Guobin Xie1 ; Ji Xia ; Dan Su ; Jie Liu ; Fuquan Jiang ; jiangfq@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yang Xu ; xuyang@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; LC&ndash ; MS/MS ; liquid chromatography&ndash ; mass spectrometry/mass spectrometry ; HPLC ; High-performance liquid chromatography ; DAVID ; Database for Annotation ; Visualization and Integrated Discovery ; STRING ; Search Tool for the Retrieval of Interacting Genes/Proteins ; ER ; endoplasmic reticulum ; KEGG ; Kyoto Encyclopedia of Genes and Genomes
- 刊名：Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1864
- 期：2
- 页码：204-210
- 全文大小：1365 K
文摘
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A SILAC-based quantitative proteomic study of TBMS1's anti-tumor cytotoxicity
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29 ribosomal proteins were differentially up-regulated by TBMS1 in NCI-H460 cells.
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TBMS1 treatment induced nucleolar stress of NCI-H460 and activated p53/MDM2, mTOR and NF-κB signaling pathways.