Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes

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• 作者：Giovanna Muscogiuri¹ ; Ralph A. DeFronzo² ; Amalia Gastaldelli² ; ³ ; ^{amalia@ifc.cnr.it} ; Jens J. Holst⁴
• 关键词：appetite ; central nervous system ; glucagon-like peptide-1 ; neurodegenerative diseases ; type 2 diabetes
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：28
• 期：2
• 页码：88-103
• 全文大小：2931 K
• 卷排序：28

文摘

Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation of neurologic and cognitive functions. These actions are mediated via neurons in the nucleus of the solitary tract that project to multiple regions expressing GLP-1 receptors (GLP-1Rs). Treatment with GLP-1R agonists (GLP-1-RAs) reduces ischemia-induced hyperactivity, oxidative stress, neuronal damage and apoptosis, cerebral infarct volume, and neurologic damage, after cerebral ischemia, in experimental models. Ongoing human trials report a neuroprotective effect of GLP-1-RAs in Alzheimer's and Parkinson's disease. In this review, we discuss the role of GLP-1 and GLP-1-RAs in the nervous system with focus on GLP-1 actions on appetite regulation, glucose homeostasis, and neuroprotection.