Human hepatitis B viral e antigen and its precursor P20 inhibit T lymphocyte proliferation

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• 作者：Maija Purvina ; Astrid Hoste ; Jean-Michel Rossignol ; Cé ; cile Lagaudriè ; re-Gesbert ; ^{cecile.lagaudriere-gesbert@u-psud.fr}
• 关键词：Hepatitis B virus ; e Antigen ; T lymphocyte ; Proliferation ; Immunoregulation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2012
• 出版时间：27 January 2012
• 年：2012
• 卷：417
• 期：4
• 页码：1310-1315
• 全文大小：683 K

文摘

The hepatitis B virus (HBV) Precore protein is processed through the secretory pathway directly as HBeAg or with the generation of an intermediate (P20). Precore gene has been shown to be implicated in viral persistence, but the functions of HBeAg and its precursors have not been fully elucidated. We show that the secreted proteins HBeAg and P20 interact with T cell surface and alter Kit-225 and primary T cells proliferation, a process which may facilitate the establishment of HBV persistence. Our data indicate that the N-terminal end of Precore is important for these inhibitory effects and exclude that they are dependent on the association of HBeAg and P20 with two characterized cell surface ligands, the Interleukin-1 Receptor Accessory Protein and gC1qR (present study).