Hepatic Resection for Noncolorectal, Nonneuroendocrine Metastases

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• 作者：Fernando Cordera ; David J. Rea ; Manuel Rodriguez-Davalos ; Tanya L. Hoskin ; David M. Nagorney and Florencia G. Que
• 刊名：Journal of Gastrointestinal Surgery
• 出版年：2005
• 出版时间：1 December 2005
• 年：2005
• 卷：9
• 期：9
• 页码：1361-1370
• 全文大小：362 K

文摘

Resection of certain hepatic metastases of noncolorectal, nonneuroendocrine (NCNNE) origin provides actual long-term (>5 years) survival. We conducted a retrospective outcome study at a single tertiary referral institution. Between January 1988 and October 1998, 64 consecutive patients underwent resection of hepatic metastases from NCNNE primary tumors. Overall and disease-free survival rates were correlated to clinicopathologic factors and operative morbidity and mortality. Thirteen patients underwent a right hepatectomy, 6 underwent a left hepatectomy, 3 had extended right and 2 extended left hepatectomy, 2 patients had segmentectomy, 24 underwent wedge resections, and 14 underwent a combination of these forms of resection. R0 resection was achieved in 56 patients (87.5 % ). The operative mortality was 1.5 % (1 of 64). Actual 1-, 3-, and 5-year survivals were 81 % , 43 % , and 30 % , respectively. The factor adversely associated with overall and disease-free survival was uniformly related to the interval between primary tumor resection and the development of hepatic metastases. A 1.5 % operative mortality and an actual 5-year survival of 30 % justifies hepatic resection, including major hepatic resection, for certain NCNNE metastases. The factor affecting prognosis in this highly select group of patients was the biological behavior of the tumor, with tumors that metastasize earlier having poorer survival rates.