Transcriptional repression of HER2 by ANO1 Cl⁻ channel inhibition in human breast cancer cells with resistance to trastuzumab

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• 作者：Mayu Fujimoto^a ; ¹ ; Takahiro Inoue^a ; ¹ ; Hiroaki Kito^a ; Satomi Niwa^a ; Takayoshi Suzuki^b ; Katsuhiko Muraki^c ; Susumu Ohya^a ; ^{sohya@mb.kyoto-phu.ac.jp}
• 关键词：Breast cancer ; HER2 ; Resistance to HER2-targeted therapy ; Ca2+-activated Cl&minus ; channel ; ANO1 ; IGFBP5
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：482
• 期：1
• 页码：188-194
• 全文大小：862 K
• 卷排序：482

文摘

HER2-positive BCA cells overexpress Ca2+-activated Cl− channel ANO1. HER2-positive BCA YMB-1 cells are resistant to trastuzumab. ANO1 inhibition induces transcriptional repression of HER2 in YMB-1 cells. HDAC3 inhibition induces transcriptional repression of HER2 via ANO1 in YMB-1 cells. ANO1 inhibition does not affect IGFBP5 transcription in YMB-1 cells.